Menu
TWO2®
MULTI-MODALITY OXYGEN
TWO2® therapy has a three component mechanism
Non-healing wounds that stall in the inflammatory phase lack adequate oxygen, which prevents essential enzymic production responsible for cellular metabolism, collagen production and immune response to fight infection. TWO2® provides the highest penetration of oxygen into the wounded tissue through an oxygen partial pressure of approximately 800 mmHg.
The extra availability of oxygen propels the wound out of the inflammatory phase and restores a robust healing pathway
The higher level of oxygen provides fuel for ATP synthesis that stimulates the wound to progress out of the stalled Inflammatory state.
The high diffusion gradient causes oxygen molecules to rapidly migrate into the hypoxic wound bed, effectively driving oxygen during the therapy into deep penetrating wounds.
A nebulizer delivers particulate humidity to the chamber to create an ideal moist wound healing environment. A moist wound bed allows for fast epithelial cell migration, which promotes healing.
The higher level of oxygen provides fuel for ATP synthesis that stimulates the wound to progress out of the stalled Inflammatory state.
All wounds need oxygen to heal. Chronic wounds can become hypoxic, or low in oxygen. The Extremity Chamber (or “Boot”) gives the wound the oxygen it needs to heal. At the same time, compression from the Boot improves blood flow to help reduce swelling (edema). Lastly, humidification ensures an ideal wound healing environment.
TWO2 therapy is designed with the patient in mind. You can use the therapy in your home while watching TV or reading a book. At the start of therapy, an ESE Ekcperts representative will drop the equipment off at your home and teach you how to begin a therapy session. Our Patient Guide walks you through each of the steps in case you want a reminder after the representative leaves your home. If you have any questions or concerns, our representatives and customer service teams are just a phone call away.
You can often wear your usual dressings and/or total contact casts (TCCs) underneath the Extremity Chamber (Boot). Your doctor will tell you if your dressings are compatible with TWO2 therapy or if they must be removed before therapy.
– Faster healing*1,2
– Reduces wound recurrence rates1,2
– Prevents amputations and hospitalizations3
– Reduces pain2
*Compared to Standard of Care. Standard of Care for DFU includes offloading, dressing that provides a moist wound healing environment, exudate management and debridement of necrotic tissue. Standard of Care for VLU includes multi-layer gradient compression dressings, dressings that provide a moist wound healing environment, exudate management and debridement of necrotic tissue.
Frykberg R, Franks P, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical Topical Wound Oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care, 2020.
Tawfick WA, Sultan, S. Technical and Clinical Outcome of Topical Wound Oxygen in Comparison to Conventional Compression Dressings in the Management of Refractory Nonhealing Venous Ulcers. Vascular and Endovascular Surgery, 2012.
Yellin J, et al. Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes. Advances in Wound Care, 2021.
The Healing Power Of TWO2® In Flexible Form: MULTI-PATCH
The TWO2® Multi-Patch system can be applied almost anywhere on the body.* The Multi-Patch can be sized for different wounds and customized to accommodate a wide variety of ulcer sizes or shapes. In addition, it can be used over gas-permeable dressings.
*Multi-Patch is contraindicated for patients with current deep vein thrombosis (DVT), or a history of DVT.
**Prescribers may determine alternative frequency or duration depending on an individual patient’s medical needs
The high diffusion gradient causes oxygen molecules to rapidly migrate into the hypoxic wound bed, effectively driving oxygen during the therapy into deep penetrating wounds.
A nebulizer delivers particulate humidity to the chamber to create an ideal moist wound healing environment. A moist wound bed allows for fast epithelial cell migration, which promotes healing.
Headquartered in Beirut, Lebanon, Mediline reaches customers all over the country, mainly medical centers, hotels and food & beverage plants, employing more than 70 associates who strive to excel in three areas which we believe to be the cornerstone of continuing success…
